Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease

0449679 - BC 2016 RIV AT eng J - Journal Article
Lake, A.D. - Novák, Petr - Shipkova, P. - Aranibar, N. - Robertson, D.G. - Reily, M.D. - Lehman-McKeeman, L.D. - Vaillancourt, R.R. - Cherrington, N.J.
Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease.
Amino Acids. Roč. 47, č. 3 (2015), s. 603-615. ISSN 0939-4451. E-ISSN 1438-2199
Institutional support: RVO:60077344
Keywords : Branched chain amino acid * nonalcoholic fatty liver disease * nonalcoholic steatohepatitis * metabolomics and transcriptomics
Subject RIV: CE - Biochemistry
Impact factor: 3.196, year: 2015

Nonalcoholic fatty liver disease (NAFLD) is a globally widespread disease of increasing clinical significance. The pathological progression of the disease from simple steatosis to nonalcoholic steatohepatitis (NASH) has been well defined, however, the contribution of altered branched chain amino acid metabolomic profiles to the progression of NAFLD is not known. The three BCAAs: leucine, isoleucine and valine are known to mediate activation of several important hepatic metabolic signaling pathways ranging from insulin signaling to glucose regulation. The purpose of this study is to profile changes in hepatic BCAA metabolite levels with transcriptomic changes in the progression of human NAFLD to discover novel mechanisms of disease progression. Metabolomic and transcriptomic data sets representing the spectrum of human NAFLD (normal, steatosis, NASH fatty, and NASH not fatty livers) were utilized for this study.
Permanent Link: http://hdl.handle.net/11104/0251177