Phosphatidylinositol 4-kinases: Function, structure, and inhibition

0449209 - ÚOCHB 2016 RIV US eng J - Journal Article
Bouřa, Evžen - Nencka, Radim
Phosphatidylinositol 4-kinases: Function, structure, and inhibition.
Experimental Cell Research. Roč. 337, č. 2 (2015), s. 136-145. ISSN 0014-4827. E-ISSN 1090-2422
R&D Projects: GA ČR GJ15-21030Y; GA MŠMT LO1302; GA ČR GA15-09310S
EU Projects: European Commission(XE) 333916 - STARPI4K
Institutional support: RVO:61388963
Keywords : phosphatidylinositol 4-kinase * inhibitor * crystal structure * virus
Subject RIV: CC - Organic Chemistry
Impact factor: 3.378, year: 2015

The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the membranes of Golgi and trans-Golgi network (TGN) and regulates trafficking to and from the Golgi. Humans have two type II PI4Ks (alpha and beta) and two type III enzymes (alpha and beta). Recently, the crystal structures were solved for both type II and type III kinase revealing atomic details of their function. Importantly, the type III PI4Ks are hijacked by +RNA viruses to create so-called membranous web, an extensively phosphorylated and modified membrane system dedicated to their replication. Therefore, selective and potent inhibitors of PI4Ks have been developed as potential antiviral agents. Here we focus on the structure and function of PI4Ks and their potential in human medicine.
Permanent Link: http://hdl.handle.net/11104/0250870