Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats

0448316 - FGÚ 2016 RIV US eng J - Journal Article
Alánová, Petra - Husková, Z. - Kopkan, L. - Sporková, A. - Jíchová, Š. - Neckář, Jan - Imig, J. D. - Klevstig, Martina - Kolář, František - Reddy, N. R. - Falck, J. R. - Sadowski, J. - Nishiyama, A. - Kramer, H. J. - Melenovský, V. - Červenková, L. - Kujal, P. - Vernerová, Z. - Červenka, L.
Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.
Vascular Pharmacology. Roč. 73, Oct 2015 (2015), s. 45-56. ISSN 1537-1891. E-ISSN 1879-3649
R&D Projects: GA ČR(CZ) GA15-08066S; GA ČR(CZ) GAP303/12/1162
Institutional support: RVO:67985823
Keywords : renovascular hypertension * myocardial ischemia/reperfusion injury * 14,15-epoxyeicosatrienoic acid analog * renin-angiotensin system
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 2.500, year: 2015

We examined the effects of a novel orally active 14,15-epoxyeicosatrienoic acid analog (EET-A) on blood pressure (BP) and myocardial infarct size (IS) in two-kidney, one-clip (2K1C) Goldblatt hypertensive rats during sustained phase of hypertension. Our findings suggest that during the phase of sustained hypertension 2K1C Goldblatt hypertensive rats exhibit increased cardiac tolerance to I/R injury as compared with normotensive controls, and that in this animal model of human renovascular hypertension short-term treatment with EET-A does not induce any antihypertensive and cardioprotective actions
Permanent Link: http://hdl.handle.net/11104/0250053