Iron oxides in human spleen

0447822 - ÚACH 2016 RIV GB eng J - Journal Article
Kopáni, M. - Miglierini, M. - Lančok, Adriana - Dekan, J. - Čaplovicová, M. - Jakubovský, J. - Boča, R. - Mrazova, H.
Iron oxides in human spleen.
Biometals. Roč. 28, č. 5 (2015), s. 913-928. ISSN 0966-0844. E-ISSN 1572-8773
Institutional support: RVO:61388980
Keywords : diffraction * iron * magnetic properties
Subject RIV: CA - Inorganic Chemistry
Impact factor: 2.134, year: 2015

Iron is an essential element for fundamental cell functions and a catalyst for chemical reactions. Three samples extracted from the human spleen were investigated by scanning (SEM) and transmission electron microscopy (TEM), Mossbauer spectrometry (MS), and SQUID magnetometry. The sample with diagnosis of hemosiderosis (H) differs from that referring to hereditary spherocytosis and the reference sample. SEM reveals iron-rich micrometer-sized aggregate of various structures-tiny fibrils in hereditary spherocytosis sample and no fibrils in hemochromatosis. Hematite and magnetite particles from 2 to 6mum in TEM with diffraction in all samples were shown. The SQUID magnetometry shows different amount of diamagnetic, paramagnetic and ferrimagnetic structures in the tissues. The MS results indicate contribution of ferromagnetically split sextets for all investigated samples. Their occurrence indicates that at least part of the sample is magnetically ordered below the critical temperature. The iron accumulation process is different in hereditary spherocytosis and hemosiderosis. This fact may be the reason of different iron crystallization.
Permanent Link: http://hdl.handle.net/11104/0249643