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Development of Thermosensitive Hydrogels of Chitosan, Sodium and Magnesium Glycerophosphate for Bone Regeneration Applications
- 1.0444730 - FGÚ 2016 RIV CH eng J - Journal Article
Lišková, Jana - Bačáková, Lucie - Skwarczyńska, A. L. - Musial, O. - Bliznuk, V. - De Schamphelaere, K. - Modrzejewska, Z. - Douglas, T.E.L.
Development of Thermosensitive Hydrogels of Chitosan, Sodium and Magnesium Glycerophosphate for Bone Regeneration Applications.
Journal of Functional Biomaterials. Roč. 6, č. 2 (2015), s. 192-203. ISSN 2079-4983
R&D Projects: GA MŠMT(CZ) EE2.3.30.0025
Institutional support: RVO:67985823
Keywords : chitosan * magnesium * mineralization
OECD category: Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions (pharmacogenomics, gene-based therapeutics)
Chitosan hydrogels could be formed by partial substitution of Na-beta-GP with Mg-GP at a molar ratio of 90:10. Gelation speeds were similar for chitosan/Na-beta-GP and chitosan/Na-beta-GP/Mg-GP hydrogels. Both hydrogel types were mineralized with apatite to a similar degree after incubation in SBF for 7 days. Both hydrogel types showed good and comparable cytocompatibility
Permanent Link: http://hdl.handle.net/11104/0247242
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