IB-MECA, an Adenosine A(3) Receptor Agonist, Does Not Influence Survival of Lethally gamma-Irradiated Mice

0440789 - BFÚ 2015 RIV CZ eng J - Journal Article
Hofer, Michal - Pospíšil, Milan - Dušek, L. - Hoferová, Zuzana - Komůrková, Denisa
IB-MECA, an Adenosine A(3) Receptor Agonist, Does Not Influence Survival of Lethally gamma-Irradiated Mice.
Physiological Research. Roč. 61, č. 6 (2012), s. 649-654. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GA305/08/0158; GA ČR(CZ) GAP303/11/0128
Institutional support: RVO:68081707
Keywords : Mouse * IB-MECA * Adenosine A(3) receptor agonist
Subject RIV: BO - Biophysics
Impact factor: 1.531, year: 2012

In our previous studies, IB-MECA, an adenosine A(3) receptor agonist, was found to stimulate proliferation of hematopoietic progenitor and precursor cells in mice. This property of IB-MECA was considered to be responsible for its ability to support regeneration of suppressed hematopoiesis after irradiation with sublethal doses of y-rays when the drug was given in a post-irradiation treatment regimen. This study was aimed at assessing the ability of IB-MECA to influence a 30-day survival of lethally irradiated mice. In a series of experiments, IB-MECA was administered following various lethal radiation doses in various numbers of drug doses and various administration routes. Though in some of these experiments a moderate increase in 30-day survival was observed in IB-MECA-treated mice, the differences in comparison with the controls were not significantly different.
Permanent Link: http://hdl.handle.net/11104/0243906