0437648 - FGÚ 2015 RIV CZ eng J - Journal Article
Brožíčková, Carole - Mikulecká, Anna - Otáhal, Jakub
Effect of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, on behavioral and physiological parameters.
Physiological Research. Roč. 63, č. 5 (2014), s. 637-648. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GAP303/10/0999; GA ČR(CZ) GPP304/11/P386; GA ČR(CZ) GBP304/12/G069
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : 7-nitroindazole * open field test * ladder rung walking test * brain excitability * blood gas analysis * rat
Subject RIV: FH - Neurology
Impact factor: 1.293, year: 2014

Present study elucidate effect of an inhibitor of neuronal nitric oxide synthase on behavioral and physiological parameters. Our results show that in conscious rats 7-NI induces a rise in arterial blood pressure and significantly alters level of blood gases. 7-NI moreover affects locomotion and exploratory activity and induces walking incoordination and increases cortical excitability as revealed by electrophysiology
Permanent Link: http://hdl.handle.net/11104/0241162