Electron hopping through proteins

0437102 - ÚFCH JH 2015 RIV NL eng J - Journal Article
Warren, J. J. - Ener, M. E. - Vlček, Antonín - Winkler, J. R. - Gray, H. B.
Electron hopping through proteins.
Coordination Chemistry Reviews. Roč. 256, 21-22 (2012), s. 2478-2487. ISSN 0010-8545. E-ISSN 1873-3840
R&D Projects: GA MŠMT(CZ) ME10124
Institutional support: RVO:61388955
Keywords : electron transfer * multistep tunneling * hopping maps
Subject RIV: CG - Electrochemistry
Impact factor: 11.016, year: 2012

Biological redox machines require efficient transfer of electrons and holes for function. Reactions involving multiple tunneling steps, termed "hopping," often promote charge separation within and between proteins that is essential for energy storage and conversion. Here we show how semiclassical electron transfer theory can be extended to include hopping reactions: graphical representations (called hopping maps) of the dependence of calculated two-step reaction rate constants on driving force are employed to account for flow in a rhenium-labeled azurin mutant as well as in two structurally characterized redox enzymes, DNA photolyase and MauG. Analysis of the 35 angstrom radical propagation in ribonucleotide reductases using hopping maps shows that all tyrosines and tryptophans on the radical pathway likely are involved in function. We suggest that hopping maps can facilitate the design and construction of artificial photosynthetic systems for the production of fuels and other chemicals. (C) 2012 Elsevier B.V. All rights reserved.
Permanent Link: http://hdl.handle.net/11104/0240667