Susceptibility of rats with altered thyroid status to malignant arrhythmias is primarily related to myocardial levels of connexin-43 and can be partially ameliorated by supplementation with red palm oil

0435701 - FGÚ 2015 RIV CA eng J - Journal Article
Bačová, B. - Vinczenzová, C. - Žurmanová, J. - Kašparová, Dita - Knezl, V. - Radošinská, J. - Beňová, T. - Pavelka, Stanislav - Soukup, Tomáš - Tribulová, N.
Susceptibility of rats with altered thyroid status to malignant arrhythmias is primarily related to myocardial levels of connexin-43 and can be partially ameliorated by supplementation with red palm oil.
Experimental and Clinical Cardiology. Roč. 18, Suppl A (2013), 41A-46A. ISSN 1205-6626
R&D Projects: GA MŠMT(CZ) 7AMB12SK158; GA ČR(CZ) GA305/09/1228; GA ČR(CZ) GAP304/12/0259
Grant - others:Univerzita Karlova(CZ) 628412
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : thyroid hormones * cardiac arrhythmias * connexin-43 * PKC.epsilon * red palm oil
Subject RIV: ED - Physiology
Impact factor: 0.758, year: 2013

We aimed to explore relationship between myocardial electrical coupling protein connexin-43 (Cx43) and susceptibility of rats with altered thyroid status to malignant arrhythmias and to examine possible beneficial effect of red palm oil (RPO). We conclude that there is an inverse relationship between myocardial Cx43 expression and heart susceptibility of rats with altered thyroid status to VF, whereby PKC.epsilon can also be involved. RPO intake increased threshold for induction of VF in the TH rats, apparently again due to up-regulation of Cx43 and PKC.epsilon
Permanent Link: http://hdl.handle.net/11104/0239522