0435694 - MBÚ 2015 RIV US eng J - Journal Article
Lukešová, E. - Bouček, Jan - Rotnáglová, E. - Salaková, M. - Koslabová, E. - Grega, M. - Eckschlager, T. - Říhová, Blanka - Procházka, B. - Klozar, J. - Tachezy, R.
High level of Tregs is a positive prognostic marker in patients with HPV-positive oral and oropharyngeal squamous cell carcinomas.
BioMed Research International. Roč. 2014, APR 2014 (2014). ISSN 2314-6133. E-ISSN 2314-6141
R&D Projects: GA MZd(CZ) NT11542
Institutional support: RVO:61388971
Keywords : Human papillomavirus * mRNA * lymphocyte
OECD category: Immunology
Impact factor: 1.579, year: 2014

Human papillomaviruses (HPVs) have been proved as one of the etiological factors of oropharyngeal squamous cell carcinoma (OPSCC). Patients with tumors of viral etiology have a lower recurrence rate and better prognosis. OPSCC is linked to an alteration in the immune system. Only a limited number of studies have correlated both the immunological parameters and HPV status with patient prognosis. The aim of this study was to determine whether HPV infection and the immunological status influence patient prognosis individually or in concurrence.Sixty patients with oral and oropharyngeal carcinomas were enrolled. They were divided into HPV-positive and HPV-negative groups based on the expression of HPV 16 E6 mRNA. Basic lymphocyte subpopulations were determined in the peripheral blood by means of flow cytometry.
Permanent Link: http://hdl.handle.net/11104/0239513