Beneficial effect of human induced pluripotent stem cell-derived neural precursors in spinal cord injury repair

0435646 - ÚEM 2016 RIV US eng J - Journal Article
Romanyuk, Nataliya - Amemori, Takashi - Turnovcová, Karolína - Procházka, Pavel - Onteniente, B. - Syková, Eva - Jendelová, Pavla
Beneficial effect of human induced pluripotent stem cell-derived neural precursors in spinal cord injury repair.
Cell Transplantation. Roč. 24, č. 9 (2015), s. 1781-1797. ISSN 0963-6897. E-ISSN 1555-3892
R&D Projects: GA MŠMT LH12024; GA ČR(CZ) GA13-00939S; GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT(CZ) LO1309
Institutional support: RVO:68378041
Keywords : human induced pluripotent stem cells * neural precursors * spinal cord injury
Subject RIV: FH - Neurology
Impact factor: 3.427, year: 2015

Neural precursors differentiated from induced pluripotent stem cells were grafted into rat spinal cord injury. They survived well and slowly mature into different neuronal phenotypes (GABAergic, serotonergic and motoneurons). In addition, they produced growth factors, stimulating neuronal sprouting. As a result, animals with spinal cord injury significantly improved their motor function. Rats were able to support their body weight and perform stepping, so they scored well in tests requiring movement coordination, such as beam walking or rotarod.
Permanent Link: http://hdl.handle.net/11104/0252351