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Diastereoselective and one-pot synthesis of trans-isoquinolonic acids via three-component condensation of homophthalic anhydride, aldehydes, and ammonium acetate catalyzed by aspartic acid
- 1.0435612 - FZÚ 2015 RIV GB eng J - Journal Article
Ghorbani-Choghamarani, A. - Hajjami, M. - Norouzi, M. - Abbasityula, Y. - Eigner, Václav - Dušek, Michal
Diastereoselective and one-pot synthesis of trans-isoquinolonic acids via three-component condensation of homophthalic anhydride, aldehydes, and ammonium acetate catalyzed by aspartic acid.
Tetrahedron. Roč. 69, č. 32 (2013), s. 6541-6544. ISSN 0040-4020. E-ISSN 1464-5416
Grant - others:AV ČR(CZ) AP0701
Program: Akademická prémie - Praemium Academiae
Institutional support: RVO:68378271
Keywords : isoquinolonic acid * diastereoselective * aldehyde * homophthalic anhydride * ammonium acetate
Subject RIV: CC - Organic Chemistry
Impact factor: 2.817, year: 2013
Aspartic acid has been developed as a versatile and highly efficient organocatalyst for the three component combination of homophthalic anhydride, aldehydes, and ammonium acetate to afford transisoquinolonic acids. The reactions were carried out in acetonitrile under reflux conditions. Aspartic acid as an efficient organocatalyst exhibits dramatically improved diastereoselectivity compared with previously reported catalysts for this synthetic strategy.
Permanent Link: http://hdl.handle.net/11104/0239422
Number of the records: 1