A Low-Molecular Weight Dialyzable Leukocyte Extract Selectively Enhances the Development of CD4+RORt+ T Cells and IL-17 Production

0435536 - ÚEM 2015 RIV CZ eng J - Journal Article
Zajícová, Alena - Javorková, Eliška - Trošan, Peter - Chudíčková, Milada - Krulová, Magdaléna - Holáň, Vladimír
A Low-Molecular Weight Dialyzable Leukocyte Extract Selectively Enhances the Development of CD4+RORt+ T Cells and IL-17 Production.
Folia Biologica. Roč. 60, č. 6 (2014), s. 253-260. ISSN 0015-5500. E-ISSN 0015-5500
R&D Projects: GA MŠMT LO1309
Institutional support: RVO:68378041
Keywords : enzyme-linked immunosorbent assay * interferon * interleukin
Subject RIV: EC - Immunology
Impact factor: 1.000, year: 2014

A low-molecular weight dialyzable leukocyte extract (called transfer factor) has been used for many years in clinic to improve or modulate immune response. However, the mechanism of its action remained obscure. Here we showed that transfer factor modulates the production of various cytokines by activated T cells and that the most profound immunoregulatory effect of transfer factort can be seen on the development of Th17 cells and interleukin-17 productiion. Transfer factor significantly enhanced the production of proinflammatory cytokine IL-17.
Permanent Link: http://hdl.handle.net/11104/0240226