Granulocyte Colony-Stimulating Factor in the Treatment of Acute Radiation Syndrome: A Concise Review

0435167 - BFÚ 2015 RIV CH eng J - Journal Article
Hofer, Michal - Pospíšil, Milan - Komůrková, Denisa - Hoferová, Zuzana
Granulocyte Colony-Stimulating Factor in the Treatment of Acute Radiation Syndrome: A Concise Review.
Molecules. Roč. 19, č. 4 (2014), s. 4770-4778. E-ISSN 1420-3049
R&D Projects: GA ČR(CZ) GAP303/11/0128
Institutional support: RVO:68081707
Keywords : granulocyte colony-stimulating factor * radiation accidents * acute radiation syndrome
Subject RIV: BO - Biophysics
Impact factor: 2.416, year: 2014

This article concisely summarizes data on the action of one of the principal and best known growth factors, the granulocyte colony-stimulating factor (G-CSF), in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highlighted are the topics of its real or anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with other drugs, the ability of other agents to stimulate endogenous G-CSF production, as well as of the capability of this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be expected to remain or even grow in the future.
Permanent Link: http://hdl.handle.net/11104/0239093