Simulation-based design of a microfabricated pneumatic electrospray nebulizer

0434464 - ÚIACH 2015 RIV DE eng J - Journal Article
Járvás, G. - Grym, Jakub - Foret, František - Guttman, A.
Simulation-based design of a microfabricated pneumatic electrospray nebulizer.
Electrophoresis. Roč. 36, č. 3 (2015), s. 386-392. ISSN 0173-0835. E-ISSN 1522-2683
R&D Projects: GA ČR(CZ) GBP206/12/G014
Institutional support: RVO:68081715
Keywords : CFD * microfabrication * modeling * electrospray * nebulizer
Subject RIV: CB - Analytical Chemistry, Separation
Impact factor: 2.482, year: 2015

A microfabricated pneumatic electrospray nebulizer has been developed and evaluated using computer simulations and experimental measurements of the mass spectrometry signals. The microdevice under development is designed for electrospray mass spectrometry interfacing without the need to fabricate an electrospray needle and can be used as a disposable or an integral part of a reusable system. The design of the chip layout was supported by computational fluid dynamics simulations. The tested microdevices were fabricated in glass using conventional photolithography, followed by wet chemical etching and thermal bonding. The performance of the microfabricated nebulizer was evaluated by means of time-of-flight mass spectrometry with a peptide mixture. It was demonstrated that the nebulizer, operating at supersonic speed of the nebulizing gas, produced very stable nanospray (900 nl/min) as documented by less than 0.1 % (standard error) fluctuation in total mass spectrometric signal intensity.
Permanent Link: http://hdl.handle.net/11104/0238535