The Gene Expression of Human Endothelial Cells Is Modulated by Subendothelial Extracellular Matrix Proteins: Short-Term Response to Laminar Shear Stress

0434379 - FGÚ 2015 RIV US eng J - Journal Article
Chlupáč, Jaroslav - Filová, Elena - Havlíková, Jana - Matějka, R. - Riedel, Tomáš - Houska, Milan - Brynda, Eduard - Pamula, E. - Rémy, M. - Bareille, R. - Fernandez, P. - Daculsi, R. - Bourget, Ch. - Bačáková, Lucie - Bordenave, L.
The Gene Expression of Human Endothelial Cells Is Modulated by Subendothelial Extracellular Matrix Proteins: Short-Term Response to Laminar Shear Stress.
Tissue Engineering. Roč. 20, 15-16 (2014), s. 2253-2264. ISSN 2152-4947
R&D Projects: GA ČR(CZ) GAP108/10/1106; GA ČR(CZ) GAP108/11/1857; GA ČR(CZ) GA305/08/0108; GA ČR GAP205/12/1702; GA MŠMT(CZ) EE2.3.30.0029; GA MŠMT(CZ) ED1.1.00/02.0109; GA MZd(CZ) NT11270
Grant - others:GA MŠk(CZ) Barrande 2005-06-036-1
Institutional support: RVO:67985823 ; RVO:61389013
Keywords : atherosclerosis * endothelial cells * extracellular matrix proteins * tissue engineering
Subject RIV: EI - Biotechnology ; Bionics; CD - Macromolecular Chemistry (UMCH-V)
Impact factor: 4.448, year: 2014

Vascular surgery for atherosclerosis is confronted by the lack of a suitable bypass material. Tissue engineering strives to produce bio-artificial conduits to provide resistance to thrombosis. The objectives of our study were to culture endothelial cells (EC) on composite assemblies of extracellular matrix proteins, and to evaluate the cellular phenotype under flow
Permanent Link: http://hdl.handle.net/11104/0238444