Number of the records: 1  

Primary Investigation of the Preparation of Nanoparticles by Precipitation

  1. 1.
    0434349 - ÚACH 2015 RIV CH eng J - Journal Article
    Vaculíková, E. - Grünwaldová, Veronika - Král, V. - Dohnal, J. - Jampílek, J.
    Primary Investigation of the Preparation of Nanoparticles by Precipitation.
    Molecules. Roč. 17, č. 9 (2012), s. 11067-11078. E-ISSN 1420-3049
    Institutional support: RVO:61388980
    Keywords : steroids * nanoparticles * precipitation * excipients * dynamic light scattering
    Subject RIV: CA - Inorganic Chemistry
    Impact factor: 2.428, year: 2012

    The absorption, distribution, biotransformation and excretion of a drug involve its transport across cell membranes. This process is essential and influenced by the characteristics of the drug, especially its molecular size and shape, solubility at the site of its absorption, relative lipid solubility, etc. One of the progressive ways for increasing bioavaibility is a nanoparticle preparation technique. Cholesterol, cholestenolone and pregnenolone acetate as model active pharmaceutical ingredients and some of the commonly used excipients as nanoparticle stabilizers were used in the investigated precipitation method that was modified and simplified and can be used as an effective and an affordable technique for the preparation of nanoparticles. All 120 prepared samples were analyzed by means of dynamic light scattering (Nanophox). The range of the particle size of the determined 100 nanoparticle samples was from 1 nm to 773 nm, whereas 82 samples contained nanoparticles of less than 200 nm. Relationships between solvents and used excipients and their amount are discussed.
    Permanent Link: http://hdl.handle.net/11104/0238428

     
     
Number of the records: 1  

  This site uses cookies to make them easier to browse. Learn more about how we use cookies.