Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast

0430431 - ÚEM 2015 RIV NL eng J - Journal Article
Večeř, J. - Veselá, Petra - Malínský, Jan - Herman, P.
Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast.
FEBS Letters. Roč. 588, č. 3 (2014), s. 443-449. ISSN 0014-5793. E-ISSN 1873-3468
R&D Projects: GA ČR GAP205/12/0720
Institutional support: RVO:68378041
Keywords : membrane microdomain * lipid order * fluidity
Subject RIV: BO - Biophysics
Impact factor: 3.169, year: 2014

We found significantly reduced abundance of gel-like microdomains in the plasma membrane of living Saccharomyces cerevisiae cells with compromised biosynthesis of sphingolipids. The phenotype could be reverted by the supply of exogenous dihydrosphingosine. The data indicate that organization of lateral microdomains is an essential physiological role of sphingolipids.
Permanent Link: http://hdl.handle.net/11104/0237201