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Crinane Alkaloids of the Amaryllidaceae with Cytotoxic Effects in Human Cervical Adenocarcinoma (HeLa) Cells
- 1.0429594 - ÚEB 2015 RIV US eng J - Journal Article
Nair, J. J. - Rárová, L. - Strnad, Miroslav - Bastida, J. - Cheesman, L. - van Staden, J.
Crinane Alkaloids of the Amaryllidaceae with Cytotoxic Effects in Human Cervical Adenocarcinoma (HeLa) Cells.
Natural Product Communications. Roč. 9, č. 4 (2014), s. 461-466. ISSN 1934-578X. E-ISSN 1555-9475
R&D Projects: GA MŠMT(CZ) LO1204
Institutional support: RVO:61389030
Keywords : Alkaloid * Amaryllidaceae * Apoptosis
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 0.906, year: 2014
The family Amaryllidaceae has a long history of usage in the traditional medicinal practices of the indigenous peoples of South Africa, with three of its species known to be used for cancer treatment. Furthermore, the Amaryllidaceae is widely recognized for its unique alkaloid constituents, several of which exhibit potent and selective cytotoxic activities. In this study, several crinane alkaloids derived from local Amaryllidaceae species were examined for cytotoxic effects against the human cervical adenocarcinoma cell line, of which distichamine was the most potent (IC50 2.2 mu M).
Permanent Link: http://hdl.handle.net/11104/0234683
Number of the records: 1