Activation of human RNase L by 5’-C-phosphonate-modified oligoadenylates

0429040 - ÚOCHB 2015 CZ eng C - Conference Paper (international conference)
Petrová, Magdalena - Buděšínský, Miloš - Zborníková, Eva - Panova, Natalya - Novák, Pavel - Rosenberg, Ivan
Activation of human RNase L by 5’-C-phosphonate-modified oligoadenylates.
Chemistry of Nucleic Acid Components. 16th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2014 - (Hocek, M.), s. 348-349. Collection Symposium Series, 14. ISBN 978-80-86241-50-0.
[Symposium on Chemistry of Nucleic Acid Components /16./. Český Krumlov (CZ), 08.06.2014-13.06.2014]
R&D Projects: GA ČR GA13-26526S; GA ČR GA13-24880S; GA TA ČR TA03010598
Institutional support: RVO:61388963
Keywords : human RNase L * oligoadenylates
Subject RIV: CC - Organic Chemistry

Adeno’sine 5’-(S)-C-phosphonate (pCOHX) was prepared as monomer suitable for oligonucleotide synthesis. Modified tetramers pCOHXAAA and pCOHXAApCOHX were assembled on solid phase and evaluated for their ability to activate human RNase L.
Permanent Link: http://hdl.handle.net/11104/0234442