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Pharmacogenetic Analysis of Captopril Effects on Blood Pressure: Possible Role of the Ednrb (Endothelin Receptor Type B) Candidate Gene
- 1.0428969 - FGÚ 2015 RIV CZ eng J - Journal Article
Zicha, Josef - Dobešová, Zdenka - Zídek, Václav - Šilhavý, Jan - Šimáková, Miroslava - Mlejnek, Petr - Vaněčková, Ivana - Kuneš, Jaroslav - Pravenec, Michal
Pharmacogenetic Analysis of Captopril Effects on Blood Pressure: Possible Role of the Ednrb (Endothelin Receptor Type B) Candidate Gene.
Physiological Research. Roč. 63, č. 2 (2014), s. 263-265. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) LH11049
Institutional support: RVO:67985823
Keywords : captopril * blood pressure * QTL * Ednrb gene * spontaneously hypertensive rat
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 1.293, year: 2014
The objective of the current study was to search for genetic determinants associated with antihypertensive effects of angiotensin-converting enzyme (ACE) inhibitor captopril. Linkage analysis of captopril-induced blood pressure effects revealed a significant quantitative trait locus (QTL) on chromosome 15 near Ednrb candidate gene. These results suggest that blood pressure lowering effects of ACE inhibitor captopril may be modulated by the variants at the Ednrb locus
Permanent Link: http://hdl.handle.net/11104/0234189
Number of the records: 1