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Biguanides Inhibit Complex I, II and IV of Rat Liver Mitochondria and Modify Their Functional Properties
- 1.0428184 - FGÚ 2015 RIV CZ eng J - Journal Article
Drahota, Zdeněk - Páleníčková, E. - Endlicher, R. - Milerová, Marie - Brejchová, Jana - Vošahlíková, Miroslava - Svoboda, Petr - Kazdová, L. - Kalous, M. - Červinková, Z. - Cahová, M.
Biguanides Inhibit Complex I, II and IV of Rat Liver Mitochondria and Modify Their Functional Properties.
Physiological Research. Roč. 63, č. 1 (2014), s. 1-11. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) LL1204; GA ČR(CZ) GAP207/12/0919
Grant - others:Univerzita Karlova(CZ) PRVOUK P37/02
Institutional support: RVO:67985823
Keywords : metformin * phenformin * mitochondrial enzymes * mitochondrial permeability transition pore * membrane fluidity
Subject RIV: ED - Physiology
Impact factor: 1.293, year: 2014
In this study we evaluated effect of biguanide phenformin on rat liver mitochondria and isolated hepatocytes. We found that phenformin dose-dependently inhibits activities of complex I, II and IV in isolated mitochondria, paralleled by the decrease of respiratory control index and mitochondrial membrane potential. The resistance of the permeability transition pore to Ca2+ ions was increased by phenformin, but without measurable effect on membrane fluidity. Our data suggest that biguanides could be considered as agents with high efficacy but low specifity
Permanent Link: http://hdl.handle.net/11104/0233587
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