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DNA Condensing Effects and Sequence Selectivity of DNA Binding of Antitumor Noncovalent Polynuclear Platinum Complexes
- 1.0427974 - BFÚ 2015 RIV US eng J - Journal Article
Malina, Jaroslav - Farrell, N. P. - Brabec, Viktor
DNA Condensing Effects and Sequence Selectivity of DNA Binding of Antitumor Noncovalent Polynuclear Platinum Complexes.
Inorganic Chemistry. Roč. 53, č. 3 (2014), s. 1662-1671. ISSN 0020-1669. E-ISSN 1520-510X
R&D Projects: GA ČR(CZ) GA13-08273S; GA MŠMT(CZ) LH13096
Institutional support: RVO:68081707
Keywords : INTERSTRAND CROSS-LINKS * LASER-LIGHT SCATTERING * CALF THYMUS DNA
Subject RIV: BO - Biophysics
Impact factor: 4.762, year: 2014
The noncovalent analogues of antitumor polynuclear platinum complexes represent a structurally discrete class of platinum drugs. Their chemical and biological properties differ significantly from those of most platinum chemotherapeutics, which bind to DNA in a covalent manner by formation of Pt-DNA adducts. In spite of the fact that these noncovalent polynuclear platinum complexes contain no leaving groups, they have been shown to bind to DNA with high affinity.
Permanent Link: http://hdl.handle.net/11104/0233407
Number of the records: 1