Number of the records: 1
Cytochrome c Is Tyrosine 97 Phosphorylated by Neuroprotective Insulin Treatment
- 1.0424725 - FGÚ 2014 RIV US eng J - Journal Article
Sanderson, T. H. - Mahapatra, G. - Pecina, Petr - Ji, Q. - Yu, K. - Sinkler, Ch. - Varughese, A. - Kumar, R. - Bukowski, M. J. - Tousignant, R. N. - Salomon, A. R. - Lee, I. - Hüttemann, M.
Cytochrome c Is Tyrosine 97 Phosphorylated by Neuroprotective Insulin Treatment.
PLoS ONE. Roč. 8, č. 11 (2013), e78627. ISSN 1932-6203. E-ISSN 1932-6203
Institutional support: RVO:67985823
Keywords : cytochrome c * tyrosine phosphorylation * brain ischemia * insulin
Subject RIV: ED - Physiology
Impact factor: 3.534, year: 2013
We investigated the phosphorylation status of Cytc in ischemic brain and sought to determine if insulin-induced neuroprotection and inhibition of Cytc release was associated with phosphorylation of Cytc. Ischemic brains demonstrated no detectable tyrosine phosphorylation. In contrast Cytc isolated from brains treated with insulin showed robust phosphorylation of Cytc, and the phosphorylation site was unambiguously identified as Tyr97 . These data suggest a mechanism whereby Cytc is targeted for phosphorylation by insulin signaling, which may prevent its release from the mitochondria and the induction of apoptosis
Permanent Link: http://hdl.handle.net/11104/0230753
Number of the records: 1