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Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications
- 1.0420861 - FGÚ 2014 RIV US eng J - Journal Article
Boulos, J. - Jakubík, Jan - Randáková, Alena - Avila, C.
Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications.
Journal of Heterocyclic Chemistry. Roč. 50, č. 6 (2013), s. 1363-1367. ISSN 0022-152X. E-ISSN 1943-5193
R&D Projects: GA ČR(CZ) GA305/09/0681
Institutional support: RVO:67985823
Keywords : N-piperidine substituted salts * muscarinic receptor antagonists * selectivity
Subject RIV: ED - Physiology
Impact factor: 0.873, year: 2013
Several heterocyclic N-piperidine substituted salts were synthesized that were found to inhibit the specific binding of the antagonists of muscarinic receptors. One of the compounds was found tobe 3 to 8 times more potent at M2 than other subtypes of muscarinic receptors in competition binding and selective for the M1 receptors over M3 and M5 in antagonizing accumulation of inositol phosphates induced by muscarinic agonist carbachol
Permanent Link: http://hdl.handle.net/11104/0227397
Number of the records: 1