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Variation within 3' UTRs of base excision repair genes and response to therapy in colorectal cancer patients: a potential modulation of microRNAs binding.
- 1.0398199 - ÚEM 2014 RIV US eng J - Journal Article
Pardini, B. - Rosa, F. - Barone, E. - Di Gaetano, C. - Slyšková, Jana - Novotný, J. - Levý, M. - Garritano, S. - Vodičková, Ludmila - Buchler, T. - Gemignani, F. - Landi, S. - Vodička, Pavel - Naccarati, Alessio
Variation within 3' UTRs of base excision repair genes and response to therapy in colorectal cancer patients: a potential modulation of microRNAs binding.
Clinical Cancer Research. Roč. 19, č. 21 (2013), s. 6044-6056. ISSN 1078-0432. E-ISSN 1557-3265
R&D Projects: GA ČR GAP304/10/1286; GA ČR(CZ) GAP304/12/1585
Institutional support: RVO:68378041
Keywords : colorectal cancer * base excision repair * survival
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 8.193, year: 2013
This study comprehensively evaluated the associations between SNPs in microRNA target binding sites of BER genes and clinical outcomes in colorectal cancer (CRC) patients. Variations in the SMUG1 gene provided biologically plausible predictors of survival, with an additional effect of 5-FU chemotherapy.
Permanent Link: http://hdl.handle.net/11104/0225720
Number of the records: 1