The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications

0397685 - ÚEM 2014 RIV FR eng J - Journal Article
Forostyak, Serhiy - Jendelová, Pavla - Syková, Eva
The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications.
Biochimie. Roč. 95, č. 12 (2013), s. 2257-2270. ISSN 0300-9084. E-ISSN 1638-6183
R&D Projects: GA ČR GA13-00939S; GA ČR GAP304/10/0320; GA ČR(CZ) GAP304/11/0189; GA ČR(CZ) GBP304/12/G069; GA MŠMT EE2.3.30.0018
Institutional support: RVO:68378041
Keywords : stem cells * regeneration * clinical trials
Subject RIV: FH - Neurology
Impact factor: 3.123, year: 2013

In the review the progress made in the cell-based therapy of spinal cord injury is discussed. An emphasis has been placed on the application of adult mesenchymal stromal cells (MSCs). The latest and most significant results from in vitro and in vivo research focusing on the regenerative/neuroprotective properties of MSCs were reviewedCorrelation of the effect of MSCs with the pathological events that are taking place in the nervous tissue after SCI was done. The results from preclinical and clinical trials involving different routes of MSC application into patients with neurological disorders of the spinal cord were discussed.
Permanent Link: http://hdl.handle.net/11104/0225891