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Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use
- 1.0397661 - ÚEM 2014 RIV GB eng J - Journal Article
Buzgo, Matej - Jakubová, Radka - Míčková, Andrea - Rampichová, Michala - Prosecká, Eva - Kochová, P. - Lukáš, D. - Amler, Evžen
Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use.
Nanomedicine. Roč. 8, č. 7 (2013), s. 1137-1154. ISSN 1743-5889. E-ISSN 1748-6963
R&D Projects: GA ČR GAP304/10/1307
Grant - others:GA UK(CZ) 330611; GA UK(CZ) 384311; GA UK(CZ) 626012; GA MŠk(CZ) ME10145; GA MZd(CZ) NT12156
Institutional research plan: CEZ:AV0Z50390703; CEZ:AV0Z50390512
Keywords : Core-shell nanofibers * alpha granules * cartilage tissue engineering
Subject RIV: FP - Other Medical Disciplines
Impact factor: 5.824, year: 2013
Alpha granules are novel source of natural growth factors from platelets. In recent work we had sucesfully embedded alpha granules into nanofibers with core/shell structure. The alpha granules survived the electrospinning proces and growth factors retained their bioaktivity as was demonstarted on the model of chondrocytes and mesenchymal stem cells.
Permanent Link: http://hdl.handle.net/11104/0225293
Number of the records: 1