The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes

0396249 - ÚEM 2014 RIV US eng J - Journal Article
Lagronová-Churavá, Svatava - Špoutil, František - Vojtěchová, Simona - Lesot, H. - Peterka, Miroslav - Klein, O. D. - Peterková, Renata
The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes.
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution Additional Title Information. Roč. 320, č. 5 (2013), s. 307-320. ISSN 1552-5007. E-ISSN 1552-5015
R&D Projects: GA ČR(CZ) GAP305/12/1766
Institutional support: RVO:68378041
Keywords : embryonic signaling center * morphogenesis * mouse odontogenesis
Subject RIV: EA - Cell Biology
Impact factor: 1.876, year: 2013

We investigated the participation of two diastemal rudiments (MS and R2) in supernumerary tooth development in Spry2 and Spry4 mutant mice by comparing morphogenesis, proliferation, apoptosis, size and Shh expression in the dental epithelium of MS and R2 rudiments and the first molar. Increased proliferation and decreased apoptosis were found in MS and R2 at embryonic day (ED) 12.5 and 13.5 in Spry2-/- embryos. Apoptosis was also decreased in both rudiments in Spry4-/- embryos, but the proliferation was lower (similar to WTmice), and supernumerary tooth development was accelerated, exhibiting a cap stage by ED13.5. Majority of the supernumerary tooth primordia degenerated prenatally, resulting in a low percentage of supernumerary teeth in adults.
Permanent Link: http://hdl.handle.net/11104/0224076