Fine needle aspiration biopsy proves increased T-lymphocyte proliferation in tumor and decreased metastatic infiltration after treatment with doxorubicin bound to PHPMA copolymer carrier

0396051 - MBÚ 2014 RIV GB eng J - Journal Article
Betka, Jaroslav - Hovorka, Ondřej - Bouček, Jan - Ulbrich, Karel - Etrych, Tomáš - Říhová, Blanka
Fine needle aspiration biopsy proves increased T-lymphocyte proliferation in tumor and decreased metastatic infiltration after treatment with doxorubicin bound to PHPMA copolymer carrier.
Journal of Drug Targeting. Roč. 21, č. 7 (2013), s. 648-661. ISSN 1061-186X. E-ISSN 1029-2330
R&D Projects: GA ČR GAP301/12/1254
Institutional support: RVO:61388971 ; RVO:61389013
Keywords : Doxorubicin conjugates * Drug targeting * Fine needle aspiration biopsy
Subject RIV: EE - Microbiology, Virology; CD - Macromolecular Chemistry (UMCH-V)
Impact factor: 2.723, year: 2013

First, mice were inoculated with mouse T-lymphoma, after 10 d the samples from tumor, lymph nodes and spleen gained by FNAB and excision were analyzed by flow cytometry. Tumor progression was compared to the control group simultaneously. Then, 10 d after tumor cell inoculation free doxorubicin (DOX) or different PHPMA DOX conjugates were injected. Cell material was analyzed to detect subpopulations of lymphocyte infiltrate, and levels of cytokines in correlation with progression or regression of the disease
Permanent Link: http://hdl.handle.net/11104/0223913