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Potentiation of Inhibitory Synaptic Transmission by Extracellular ATP in Rat Suprachiasmatic Nuclei
- 1.0392575 - FGÚ 2014 RIV US eng J - Journal Article
Bhattacharya, Anirban - Vávra, Vojtěch - Svobodová, Irena - Bendová, Z. - Vereb, G. - Zemková, Hana
Potentiation of Inhibitory Synaptic Transmission by Extracellular ATP in Rat Suprachiasmatic Nuclei.
Journal of Neuroscience. Roč. 33, č. 18 (2013), s. 8035-8044. ISSN 0270-6474. E-ISSN 1529-2401
R&D Projects: GA AV ČR(CZ) IAA500110910; GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) EE2.3.30.0025
Institutional support: RVO:67985823
Keywords : suprachiasmatic nucleus * P2X receptors * P2Y receptors * ATP * GABA * spontaneous inhibitory synaptic currents
Subject RIV: ED - Physiology
Impact factor: 6.747, year: 2013
The hypothalamic suprachiasmatic nuclei (SCN), the circadian master clock in mammals, releases ATP in a rhythm. In this study, we examined the expression and function of ATP-gated P2X receptors (P2XRs) in the SCN neurons of rat brain slices. Our data show that ATP activates presynaptic P2X2Rs to regulate inhibitory synaptic transmission within the SCN and that this effect varies between dorsomedial and ventrilateral SCN regions
Permanent Link: http://hdl.handle.net/11104/0221407
Number of the records: 1