Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats

0390670 - FGÚ 2013 RIV CH eng J - Journal Article
Vaněčková, Ivana - Kujal, P. - Husková, Z. - Vaňourková, Z. - Vernerová, Z. - Čertíková - Chábová, V. - Škaroupková, P. - Kramer, H. J. - Tesař, V. - Červenka, L.
Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats.
Kidney & Blood Pressure Research. Roč. 35, č. 5 (2012), s. 382-392. ISSN 1420-4096. E-ISSN 1423-0143
Institutional research plan: CEZ:AV0Z50110509
Keywords : 5/6 nephrectomy * Endothelin receptor type A * AT1 receptor blocker * end-organ damage * hypertension
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 1.596, year: 2012

The additive effect of endothelin-1 blockade to renin-angiotensin blockade was evaluated in rats with ablation nephrectomy. While RAS blockade normalized blood pressure (BP), improved survival, decreased cardiac hypertrophy and proteinuria as well as tissue angiotensin II and ET-1 levels, ETA receptor blockade only partially improved survival rate, reduced BP, attenuated the development of cardiac hypertrophy and transiently reduced proteinuria. No additive cardio- and renoprotective effects of ETA and RAS blockade were noted at the end of the study suggesting that the RAS system is the main target for antihypertensive treatment in models with inappropriately activated RAS
Permanent Link: http://hdl.handle.net/11104/0219579