Number of the records: 1
Effect of fluoxetine and adenosine receptor NECA agonist on G alpha q/11 protein of C6 glioma cells
- 1.0390643 - FGÚ 2013 RIV SE eng J - Journal Article
Kovářů, H. - Kovářů, F. - Lisá, Věra
Effect of fluoxetine and adenosine receptor NECA agonist on G alpha q/11 protein of C6 glioma cells.
Neuroendocrinology Letters. Roč. 33, č. 6 (2012), s. 614-618. ISSN 0172-780X. E-ISSN 2354-4716
Institutional support: RVO:67985823
Keywords : C6 glioma cells * SSRI antidepressant * G alpha q/11 signalling * G protein coupled receptor
Subject RIV: ED - Physiology
Impact factor: 0.932, year: 2012
In C6 glioma cells, we studied acute administration of SSRI antidepressants - fluoxetine, sertraline and citalopram. We used immunochemical estimation (ELISA) of the main types of G-protein alpha subunits from isolated membranes of C6 glioma cells. We also estimated effect of NECA agonist on fluoxetine induced signalling via 1,4,5 IP3 and its levels. Presented data are first findings about adenosine receptor interaction with fluoxetine signalling. Thus in vitro studies contribute to the clarification of the molecular basis of antidepressant action
Permanent Link: http://hdl.handle.net/11104/0219516
Number of the records: 1