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Irradiated stem cells and ageing of the haematopoietic system
- 1.0390349 - BFÚ 2013 RIV US eng J - Journal Article
Vávrová, J. - Šinkorová, Z. - Řezáčová, M. - Tichý, Adam - Filip, S. - Mokrý, J. - Lukášová, Emilie
Irradiated stem cells and ageing of the haematopoietic system.
Radiation and Environmental Biophysics. Roč. 51, č. 2 (2012), s. 205-213. ISSN 0301-634X. E-ISSN 1432-2099
Institutional research plan: CEZ:AV0Z50040702
Institutional support: RVO:68081707
Keywords : Irradiation * Ageing of haematopoiesis * Anaemia
Subject RIV: BO - Biophysics
Impact factor: 1.754, year: 2012
In the work presented here, changes in haematopoiesis of mice (B6129SF2/J) were studied 1 year after their whole-body exposure to a dose of 7 Gy (72% of mice survived). The irradiated mice were compared with non-irradiated younger (4 months of age) and older (16 months of age) mice. There was a significant increase in the relative abundance of primitive stem cells with long-term capability of the haematopoiesis recovery lin(-)/Sca-1(+)/CD117(+)/CD34(-) in the bone marrow of mice aged 16 months (irradiated and non-irradiated) compared with those aged 4 months. In terms of the ability to respond to further whole-body irradiation at a dose of 1 Gy, the presence of gamma H2A.X foci was studied in lin(-) bone marrow cells.
Permanent Link: http://hdl.handle.net/11104/0219268
Number of the records: 1