Early programming of astrocyte organization in the mouse suprachiasmatic nuclei by light

0389305 - ÚEM 2013 RIV GB eng J - Journal Article
Canal, M. M. - Mohammed, N. M. - Rodríguez Arellano, Jose Julio
Early programming of astrocyte organization in the mouse suprachiasmatic nuclei by light.
Chronobiology International. Roč. 26, č. 8 (2009), s. 1545-1558. ISSN 0742-0528. E-ISSN 1525-6073
Institutional research plan: CEZ:AV0Z50390512
Keywords : Development * GFAP * Circadian rhythm
Subject RIV: FH - Neurology
Impact factor: 3.987, year: 2009

We observed that although LL-reared mice showed lowest GFAP expression in the SCN, as determined by quantification of immunostaining levels, the number of GFAP-positive cells was highest in this group, suggesting structural remodelling of SCN astrocytes by early light experience. These results indicate the postnatal light environment has long-term effects on the astrocytic population of the SCN. We argue that these neurochemical and structural alterations may affect clock function, which may in turn modify animal behavior
Permanent Link: http://hdl.handle.net/11104/0218193