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Isotope exchange reactions of the hydrogen H-5 of selected pyrimidine derivatives and the preparation of tritium-labeled pyrimidines
- 1.0388747 - ÚOCHB 2013 RIV CZ eng J - Journal Article
Dračínský, Martin - Jansa, Petr - Elbert, Tomáš
Isotope exchange reactions of the hydrogen H-5 of selected pyrimidine derivatives and the preparation of tritium-labeled pyrimidines.
Collection of Czechoslovak Chemical Communications. Roč. 76, č. 12 (2011), s. 1567-1577. ISSN 0010-0765
R&D Projects: GA AV ČR KJB400550903; GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : isotopic labeling * NMR spectroscopy * nucleobases * pyrimidines
Subject RIV: CC - Organic Chemistry
Impact factor: 1.283, year: 2011
The hydrogen-to-deuterium isotope exchange reaction of hydrogen in position 5 of pyrimidine derivatives was studied using NMR techniques. The dependence of the reaction rate on the pH and on the solvent composition was explored. In tracer experiments using tritiated water, the application of this exchange reaction was tested for the preparation of pyrimidine derivatives labeled by tritium.
Permanent Link: http://hdl.handle.net/11104/0217699
Number of the records: 1