Celiac disease markers in patients with liver diseases: A single center large scale screening study

0388690 - MBÚ 2013 RIV CN eng J - Journal Article
Drastich, P. - Honsová, E. - Lodererová, A. - Jarešová, M. - Pekáriková, Aneta - Hoffmanová, I. - Tučková, Ludmila - Tlaskalová-Hogenová, Helena - Špičák, J. - Sánchez, Daniel
Celiac disease markers in patients with liver diseases: A single center large scale screening study.
World Journal of Gastroenterology. Roč. 18, č. 43 (2012), s. 6255-6262. ISSN 1007-9327. E-ISSN 2219-2840
R&D Projects: GA AV ČR IAA500200709; GA ČR GA310/07/0414
Institutional support: RVO:61388971
Keywords : Tissue transglutaminase * Anti-tissue transglutaminase antibodies * Autoimmune liver diseases
Subject RIV: EC - Immunology
Impact factor: 2.547, year: 2012

AIM: To study the coincidence of celiac disease, we tested its serological markers in patients with various liver diseases.Large-scale screening of serum antibodies against tissue transglutaminase (tTG), and deamidated gliadin using enzyme-linked immunosorbent assay and serum antibodies against endomysium using immunohistochemistry, in patients with various liver diseases (n = 962) and patients who underwent liver transplantation (OLTx, n = 523) was performed. The expression of tTG in liver tissue samples of patients simultaneously suffering from celiac disease and from various liver diseases using immunohistochemistry was carried out. The final diagnosis of celiac disease was confirmed by histological analysis of small-intestinal biopsy
Permanent Link: http://hdl.handle.net/11104/0217602