Tritium labeling of peptides using synthetic incorporated diiodinated tyrosine amino acid residues as precursor

0388342 - ÚOCHB 2013 DE eng A - Abstract
Marek, Aleš - Baun, M. - Bruun, S. W. - Pedersen, M. H. F.
Tritium labeling of peptides using synthetic incorporated diiodinated tyrosine amino acid residues as precursor.
11th International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds. Heidelberg: -, 2012. s. 57-57.
[International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds /11./. 09.09.2012-13.09.2012, Heidelberg]
Institutional research plan: CEZ:AV0Z40550506
Keywords : tritium * labeled peptides
Subject RIV: CC - Organic Chemistry

Three peptides - gliadin-19, gliadin-33 and PACAP-38 - with N-terminal 3,5-diiodotyrosyl residue were synthesized. Reductive deiodination of these peptides by tritium gas under catalysis with 10%Pd/C afforded tritium-labeled peptides with specific activities from 16 to 29 Ci/mmol.
Permanent Link: http://hdl.handle.net/11104/0217277