Nondisjunction in Favor of a Chromosome: The Mechanism of Rye B Chromosome Drive during Pollen Mitosis

0384793 - BC 2013 RIV US eng J - Journal Article
Banaei-Moghaddam, A.M. - Schubert, V. - Kumke, K. - Weiβ, O. - Klemme, S. - Nagaki, K. - Macas, Jiří - González-Sánchez, M. - Heredia, V. - Gómez-Revilla, D. - González-García, M. - Vega, J.M. - Puertas, M.J. - Houben, A.
Nondisjunction in Favor of a Chromosome: The Mechanism of Rye B Chromosome Drive during Pollen Mitosis.
Plant Cell. Roč. 24, č. 10 (2012), s. 4124-4134. ISSN 1040-4651. E-ISSN 1532-298X
Institutional research plan: CEZ:AV0Z50510513
Keywords : chromosomes * centromere * repeats
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 9.251, year: 2012

B chromosomes (Bs) are supernumerary components of the genome and do not confer any advantages on the organisms that harbor them. The maintenance of Bs in natural populations is possible by their transmission at higher than Mendelian frequencies. Although drive is the key for understanding B chromosomes, the mechanism is largely unknown. We provide direct insights into the cellular mechanism of B chromosome drive in the male gametophyte of rye (Secale cereale). We found that nondisjunction of Bs is accompanied by centromere activity and is likely caused by extended cohesion of the B sister chromatids. The B centromere originated from an A centromere, which accumulated B-specific repeats and rearrangements. Because of unequal spindle formation at the first pollen mitosis, nondisjoined B chromatids preferentially become located toward the generative pole. The failure to resolve pericentromeric cohesion is under the control of the B-specific nondisjunction control region.
Permanent Link: http://hdl.handle.net/11104/0214319