Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer

0384590 - ÚMCH 2013 RIV GB eng J - Journal Article
Green, N. K. - Hale, A. - Cawood, R. - Illingworth, S. - Herbert, C. - Hermiston, T. - Šubr, Vladimír - Ulbrich, Karel - van Rooijen, N. - Seymour, L. W. - Fisher, K. D.
Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer.
Nanomedicine. Roč. 7, č. 11 (2012), s. 1683-1695. ISSN 1743-5889. E-ISSN 1748-6963
R&D Projects: GA AV ČR IAAX00500803
Institutional research plan: CEZ:AV0Z40500505
Institutional support: RVO:61389013
Keywords : clodronate liposomes * polymer-coated adenovirus * predosing strategy
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 5.260, year: 2012

Intravenous delivery of therapeutic virus particles remains a major goal for virotherapy of metastatic cancer. Polymer coating of adenovirus type 5 (Ad5) can combine with predosing strategies or Kupffer cell ablation to achieve systemic kinetics with a half-life >60 min, allowing ready access to peripheral tumors. Polymer coating wild-type Ad5 in this way is known to decrease hepatic toxicity, increasing the dose of virus particles that can be safely administered. Using polymer-coating technology to deliver a replicating Ad5 systemically, virus replication and transgene expression was almost totally confined to tumor tissues, giving a much improved therapeutic index compared with uncoated virus, and complete control of human HepG2 tumor xenografts.
Permanent Link: http://hdl.handle.net/11104/0216116