Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

0382291 - ÚOCHB 2013 RIV GB eng J - Journal Article
Tichý, Michal - Pohl, Radek - Xu, H. Y. - Chen, Y. L. - Yokokawa, F. - Shi, P. Y. - Hocek, Michal
Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides.
Bioorganic & Medicinal Chemistry. Roč. 20, č. 20 (2012), s. 6123-6133. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA ČR GAP207/11/0344
Institutional support: RVO:61388963
Keywords : nucleosides * deazapurines * antivirals
Subject RIV: CC - Organic Chemistry
Impact factor: 2.903, year: 2012

A series of new pyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 4 has been prepared by selective Pd-catalyzed cross-coupling reactions of the corresponding protected 4,6-dichloropyrimido[4,5-b]indole ribonucleoside with (het)arylboronic acids or stannanes followed by deprotection. Some of these compounds displayed antiviral activity against Dengue virus.
Permanent Link: http://hdl.handle.net/11104/0212553