Early Chronotype and Tissue-Specific Alterations of Circadian Clock Function in Spontaneously Hypertensive Rats

0381846 - FGÚ 2013 RIV US eng J - Journal Article
Sládek, Martin - Polidarová, Lenka - Nováková, Marta - Parkanová, Daniela - Sumová, Alena
Early Chronotype and Tissue-Specific Alterations of Circadian Clock Function in Spontaneously Hypertensive Rats.
PLoS ONE. Roč. 7, č. 10 (2012), e46951. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR(CZ) GAP303/11/0668; GA ČR(CZ) GPP305/10/P244
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : SHR * circadian system * clock gene * metabolism * colon * liver * suprachiasmatic nucleus
Subject RIV: ED - Physiology
Impact factor: 3.730, year: 2012

The study analyzed the function of the circadian system of Spontaneously hypertensive rat (SHR). The results revealed that SHR exhibited an early chronotype, because the central clock in the suprachiasmaric nuclei of the hypothalamus was phase-advanced relative to light/dark cycle. Moreover, the output rhythm was dampened. The peripheral clocks of SHR reacted to the dampened central clock with tissue-specific consequences. In the colon, the rhythms were severely altered, whereas the effect was only marginal in the liver. These results might result in mutual desynchrony of circadian oscillators within the circadian system of SHR, thereby potentially contributing to metabolic pathology of the rat strain
Permanent Link: http://hdl.handle.net/11104/0212222