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DNA conformation and repair of polymeric natural DNA damaged by antitumor azolato-bridged dinuclear PtII complex
- 1.0381588 - BFÚ 2013 RIV US eng J - Journal Article
Mlčoušková, J. - Kašpárková, Jana - Suchánková, Tereza - Komeda, S. - Brabec, Viktor
DNA conformation and repair of polymeric natural DNA damaged by antitumor azolato-bridged dinuclear PtII complex.
Journal of Inorganic Biochemistry. Roč. 114, SEP 2012 (2012), s. 15-23. ISSN 0162-0134. E-ISSN 1873-3344
R&D Projects: GA ČR(CZ) GAP301/10/0598; GA ČR(CZ) GD301/09/H004
Institutional research plan: CEZ:AV0Z50040702
Keywords : DNA * platinum * DNA repair
Subject RIV: BO - Biophysics
Impact factor: 3.197, year: 2012
The results demonstrate for the first time that little conformational distortions induced by new antitumor azolato-bridged dinuclear PtII complexes, such as [{cis-Pt(NH3)2}2(µ-OH)(µ-pyrazolate)]2+ in highly polymeric DNA with a random nucleotide sequence represent a structural motif recognizable by DNA repair systems less efficiently than distortions induced by cisplatin. Thus, DNA adducts of azolato-bridged dinuclear PtII complexes can escape repair mechanisms more easily than those of cisplatin, which may potentiate antitumor effects of these new metallodrugs in cancer cells.
Permanent Link: http://hdl.handle.net/11104/0212020
Number of the records: 1