0381219 - ÚMCH 2013 RIV DE eng J - Journal Article
Pánek, Jiří - Filippov, Sergey K. - Hrubý, Martin - Rabyk, Mariia - Bogomolova, Anna - Kučka, Jan - Štěpánek, Petr
Thermoresponsive nanoparticles based on poly(2-alkyl-2-oxazolines) and pluronic F127.
Macromolecular Rapid Communications. Roč. 33, č. 19 (2012), s. 1683-1689. ISSN 1022-1336. E-ISSN 1521-3927
R&D Projects: GA ČR GA202/09/2078; GA ČR GPP207/10/P054
Grant - others:AV ČR(CZ) M200501201
Program: M
Institutional research plan: CEZ:AV0Z40500505
Institutional support: RVO:61389013
Keywords : nanoparticles * pluronic F127 * poly(2-alkyl-2- oxazoline)s
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 4.929, year: 2012 ; AIS: 1.201, rok: 2012
DOI: https://doi.org/10.1002/marc.201200254

We synthesized statistical poly(2-isopropyl-2-oxazoline– co –2-butyl-2-oxazolines) (POXs) that are molecularly dissolved below their cloud point temperature in aqueous milieu and are incorporated into micellar nanoparticles of biocompatible Pluronic F127 (F127) after heating their solution above transition temperature, T tr . A functional comonomer 2-(but-3-enyl)-2-oxazoline copolymerized into one of the POXs (polymer E) allows introduction of fenolic moieties and subsequent radionuclide labeling with iodine-125. Self-assembly of the polymer E with F127 leads to formation of radioactive nanoparticles with hydrodynamic diameter 20 nm in aqueous solution by heating to 37° C. The nanoparticles are intended to be used as radioimaging tool in solid tumor diagnostics.
Permanent Link: http://hdl.handle.net/11104/0211740