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Integrin alpha 5 beta 1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma
- 1.0380296 - FGÚ 2013 RIV US eng J - Journal Article
Janoušková, Hana - Maglott, A. - Leger, D.Y. - Bossert, C. - Noulet, F. - Guerin, E. - Guenot, D. - Pinel, S. - Chastagner, P. - Plenat, F. - Entz-Werle, N. - Lehmann-Che, J. - Godet, J. - Martin, S. - Teisinger, Jan - Dontenwill, M.
Integrin alpha 5 beta 1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma.
Cancer Research. Roč. 72, č. 14 (2012), s. 3463-3470. ISSN 0008-5472. E-ISSN 1538-7445
Institutional support: RVO:67985823
Keywords : cancer * integrins * high-grade glioma
Subject RIV: CE - Biochemistry
Impact factor: 8.650, year: 2012
Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. Our findings indicate that negative cross-talk between a5b1 integrin and p53 supports glioma resistance to temozolomide, providing preclinical proof-of-concept that a5b1 integrin represents a therapeutic target for high-grade brain tumors. Direct activation of p53 may remain a therapeutic option in the subset of patients with high-grade gliomas that express both functional p53 and a high level of a5b1 integrin
Permanent Link: http://hdl.handle.net/11104/0211037
Number of the records: 1