0380158 - ÚOCHB 2013 RIV US eng J - Journal Article
Pazderková, Markéta - Bednárová, Lucie - Dlouhá, Helena - Flegel, Martin - Lebl, M. - Hlaváček, Jan - Setnička, V. - Urbanová, M. - Hynie, S. - Klenerová, V. - Baumruk, V. - Maloň, Petr
Electronic and Vibrational Optical Activity of Several Peptides Related to Neurohypophyseal Hormones: Disulfide Group Conformation.
Biopolymers. Roč. 97, č. 11 (2012), s. 923-932. ISSN 0006-3525. E-ISSN 1097-0282
R&D Projects: GA ČR GAP205/10/1276
Grant - others:GA UK(CZ) 578212
Institutional research plan: CEZ:AV0Z40550506
Keywords : neurohypophyseal hormones * disulfide bridge * Raman optical activity * vibrational circular dichroism
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 2.879, year: 2012

Electronic and vibrational optical activity of the set of neurohypophyseal hormones and their analogs was investigated to clarify the S-S bond solution conformation. The selected compounds include oxytocin (I), lysine vasopressin (II), arginine vasopressin (III), and their analogs (IV-IX), differing widely in their pharmacological properties. We have extended the already known electronic circular dichroism data by new information provided by vibrational circular dichroism (VCD) and Raman optical activity (ROA). The use of VCD brought additional details on three-dimensional structure of the chain reversal in the ring moiety and on its left handedness. Furthermore, Raman scattering and ROA allowed us to deduce the sense of the disulfide bond torsion.
Permanent Link: http://hdl.handle.net/11104/0210943