Effect of tetrabrombisphenol A on induction of apoptosis in the testes and changes in expression of selected testicular genes in CD1 mice

0380136 - BTÚ 2013 RIV US eng J - Journal Article
Žatecká, Eva - Děd, Lukáš - Elzeinová, Fatima - Kubátová, Alena - Dorosh, Andriy - Margaryan, Hasmik - Dostálová, Pavla - Pěknicová, Jana
Effect of tetrabrombisphenol A on induction of apoptosis in the testes and changes in expression of selected testicular genes in CD1 mice.
Reproductive Toxicology. Roč. 35, č. 1 (2013), s. 32-39. ISSN 0890-6238. E-ISSN 1873-1708
R&D Projects: GA MŠMT 2B06151; GA MŠMT 1M06011; GA MZd NS10009; GA ČR GA523/09/1793
Grant - others:GA ČR(CZ) GD524/05/H536
Program: GD
Institutional research plan: CEZ:AV0Z50520701
Keywords : tetrabromobisphenol A * fertility * reproductive parameters * spermatogenesis * histopathology of testes * apoptosis * gene expression
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.771, year: 2013

Tetrabromobisphenol A (TBBPA) is a substance widely used in industry as a flame retardant. TBBPA was found in the environment and was detected even in the human body. The effect of this chemical was observed in different cell lines in vitro and it is supposed that TBBPA may affect various hormonal systems in vivo. In this study we examined the effect of TBBPA on the reproductive parameters of two generations of outbred mice in vivo. Experimental and control animals of F1 generation were bred in various conditions to enable evaluation of the possible trans-generational effect. An increased incidence of apoptosis in the testes and changes in the morphometry of seminiferous tubules was detected in the experimental animals. In addition, changes in the expression pattern of selected genes encoding proteins that play an important role during spermatogenesis were observed. In contrast, sperm quality and reproduction were not affected by TBBPA.
Permanent Link: http://hdl.handle.net/11104/0210928