Cytoskeleton in mast cell signaling

0378914 - ÚMG 2013 RIV CH eng J - Journal Article
Dráber, Pavel - Sulimenko, Vadym - Dráberová, Eduarda
Cytoskeleton in mast cell signaling.
Frontiers in Immunology. Roč. 3, May (2012), s. 130. ISSN 1664-3224. E-ISSN 1664-3224
R&D Projects: GA ČR GAP302/10/1701; GA ČR GPP302/11/P709; GA ČR GAP302/12/1673
Grant - others:ECST(XE) Action BM1007
Institutional research plan: CEZ:AV0Z50520514
Keywords : cytoskeleton * mast cell activation * signal transduction
Subject RIV: EB - Genetics ; Molecular Biology

This review article presents a critical survey of current knowledge on the role of cytokeleton in mast cell signaling. Mast cell activation mediated by the high affinity receptor for IgE (FcεRI) is a key event in allergic response and inflammation. Activation of various signaling pathways results in changes in cell morphology, adhesion to substrate, exocytosis, and migration. Reorganization of cytoskeleton is pivotal in all these processes. Highly dynamic microtubules formed by αβ-tubulin dimers as well as microfilaments build up from polymerized actin are affected in activated cells by kinases/phosphatases, Rho GTPases and changes in concentration of cytosolic Ca2+. The dynamic nature of microtubules and microfilaments in activated cells also depends on many associated/regulatory proteins. In this review, we have summarized recent developments in the biology of cytoskeleton and the role of signaling pathways in the course of mast cell activation.
Permanent Link: http://hdl.handle.net/11104/0216408