Transition-Metal-Mediated or -Catalyzed Syntheses of Steroids and Steroid-Like Compounds

0377443 - ÚOCHB 2013 RIV DE eng J - Journal Article
Kotora, Martin - Hessler, F. - Eignerová, B.
Transition-Metal-Mediated or -Catalyzed Syntheses of Steroids and Steroid-Like Compounds.
European Journal of Organic Chemistry. -, č. 1 (2012), s. 29-42. ISSN 1434-193X. E-ISSN 1099-0690
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : steroids * synthesis design * synthetic methods * asymmetric synthesis * transition metals
Subject RIV: CC - Organic Chemistry
Impact factor: 3.344, year: 2012

This short review aims to summarize recent advances in the use of transition-metal-catalyzed and -mediated methodology for the synthesis of steroid and steroid-like skeletons reported in the last decade. The methodologies used include transition-metal-catalyzed or -mediated [2+2+2] and other cycloadditions, the Pauson-Khand reaction, cross-coupling and Heck reactions, processes based on the activation of single and multiple bonds, metathesis reactions, hydrovinylation, and other reactions. Several examples of total syntheses of steroid compounds [e.g., (+)- and (-)-estrone, desogestrel] by these procedures are presented.
Permanent Link: http://hdl.handle.net/11104/0209596