Lack of evidence for integration of Trypanosoma cruzi minicircle DNA in South American human genomes

0377105 - BC 2013 RIV AU eng J - Journal Article
Flegontova, Olga - Lukeš, Julius - Flegontov, Pavel
Lack of evidence for integration of Trypanosoma cruzi minicircle DNA in South American human genomes.
International Journal for Parasitology. Roč. 42, č. 5 (2012), s. 437-441. ISSN 0020-7519. E-ISSN 1879-0135
Grant - others:GA MŠk(CZ) LM2010005
Institutional support: RVO:60077344
Keywords : Trypanosoma cruzi * Kinetoplast minicircle * Chagas disease * Horizontal gene transfer * Human genome
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.637, year: 2012
http://www.sciencedirect.com/science/article/pii/S0020751912000781

Horizontal gene transfer involving kinetoplast DNA minicircles between Trypanosoma cruzi and its mammalian hosts has recently been proposed as a usual consequence of infection (Hecht et al., 2010). However, we have found no sequences longer than 29 bp perfectly matching minicircles of T. cruzi in the unassembled reads from Colombian and Peruvian human populations provided by the 1,000 Genome project (129 individuals in total, coverage from 1.4_ to 36.3_, read length from 42 to 101 bp). The weak sequence matches that were identified are shared with a Finnish population used as a control from a nonendemic area.
Permanent Link: http://hdl.handle.net/11104/0209355